This refers to how an allosteric modulator affects signaling for a specific orthosteric agonist. For instance, an allosteric modulator may possibly alter THC signaling, although not endogenous cannabinoid signaling. A significant probable endogenous adverse allosteric modulator for CB1 is the steroid hormone, pregnenolone [forty–42]. Some (while not all [forty three–forty https://caideniqzej.blazingblog.com/32856638/everything-about-psychoactive-effects