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DNA ligases seal five′-PO4 and 3′-OH polynucleotide finishes by means of three nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are important guardians of genomic integrity, and ligase dysfunction underlies human genetic sickness syndromes. Crystal constructions of DNA ligases bound to nucleotide and nucleic acid substrates have https://ligaz-bet-best-sports-bet30492.affiliatblogger.com/80269054/not-known-details-about-online-betting-site

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